Our question this week comes from the Nature Check discord. Nature Check is a project where we use games like D&D to talk about science, and you should totally check it out!
In the food channel, we were talking about bugs as food and the concept of cross-allergies came up. When introducing any new food into the supply chain, it’s something we have to consider because choosing the wrong food could cause a lot of people to get sick.

I’ve discussed the idea of cross-allergies in relation to wasp stings, and they all kind of work the same way. Basically, there’s something you become allergic to. Sometimes, it’s a protein and sometimes it’s a sugar or something like that. If that something is similar enough between different the different kinds of plants and animals you eat as food, you could become allergic to another kind of food.
Given how important food is to my life-I’m an agricultural scientist, after all-I like to keep up on food allergies. I hadn’t heard anything about the cricket/nut allergy connection, and wasn’t able to find any literature about it. That’s not to say that it’s never happened, but I was unable to find any evidence that was a thing.
So, it’s unlikely that kind of cross-reactivity actually exists…but there is a lot of cross-reactivity between different arthropods used as food. These are called pan-allergens because if you become allergic to one critter, suddenly you’re allergic to lots of critters.
So let’s talk about the proteins which make you allergic to everything, and why they can do that.
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